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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can reduce panobinostat degrees by ~70% and cause treatment failure.pentobarbital will decrease the level or impact of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significan